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Levothyroxine is a thyroid medicine that replaces a hormone normally produced by your thyroid gland to regulate the body’s energy and metabolism. Levothyroxine is given when your thyroid does not produce enough of this hormone on its own. Levothyroxine is used to treat hypothyroidism (low thyroid hormone). It is also used to treat or prevent goiter (enlarged thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or cancer.